Recombinant PreS-fusion protein vaccine for birch pollen and apple allergy.
Khaitov M RIgor ShilovskiyRudolph ValentaMilena WeberArtem KorneevInna TulaevaPia GattingerMarianne van HageGerhard HoferJon R KonradsenWalter KellerOluwatoyin AkinfenwaAlina PoroshinaNataliya IlinaElena FedenkoOlga ElisyutinaAlla LitovkinaEvgenii SmolnikovAleksandra NikonovaSergei RybalkinVladimir AldobaevValeriy V SmirnovNadezhda ShershakovaOlga PetukhovaDmitry Anatolievich KudlayArtem A ShatilovAnastasiia V TimofeevaRaffaela CampanaSergei UdinVeronica SkvortsovaPublished in: Allergy (2023)
The recombinant AB-PreS-based vaccine is hypoallergenic and superior over currently registered allergen extract-based vaccines regarding the induction of blocking antibodies to Bet v 1 and Mal d 1 in animals.