CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma.

Chunyan GuWang WangXiaozhu TangTingting XuYanxin ZhangMengjie GuoRongfang WeiYajun WangArtur JurczyszynSiegfried JanzMeral BeksacFenghuang ZhanAnja SeckingerDirk HoseJingxuan PanYe Yang

Published in: Molecular cancer (2021)

Our findings suggest that targeting the enzymatic catalytic center encoded by CHEK1 mRNA and circCHEK1_246aa is a promising therapeutic modality to target both MM cells and BM niche.

Keyphrases

multiple myeloma
induced apoptosis
cell cycle arrest
bone mineral density
hydrogen peroxide
cancer therapy
copy number
endoplasmic reticulum stress
oxidative stress
soft tissue
gene expression
nitric oxide
binding protein