Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Zhang MaoXu HanDahong ChenYouwei XuLina XuLianhong YinHuijun SunYan QiLingling FangKexin LiuJinyong PengPublished in: British journal of pharmacology (2019)
The data suggest that dioscin has potential as a therapeutic, and TIGAR as a drug target for treating HCC.
Keyphrases
- oxidative stress
- dna damage
- diabetic rats
- endoplasmic reticulum stress
- cell death
- drug induced
- high glucose
- cell cycle arrest
- electronic health record
- dna repair
- signaling pathway
- transcription factor
- big data
- anti inflammatory
- endothelial cells
- adverse drug
- machine learning
- human health
- emergency department
- data analysis
- artificial intelligence
- stress induced