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Selinexor decreases HIF-1α via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity.

Moritz von FalloisFriederike Katharina KosynaMarkus MandlYosef LandesmanJürgen DunstReinhard Depping
Published in: Journal of cancer research and clinical oncology (2021)
Targeting the HIF pathway by Selinexor might be an attractive tool to overcome hypoxia-induced radioresistance.
Keyphrases
  • endothelial cells
  • induced apoptosis
  • cell cycle arrest
  • induced pluripotent stem cells
  • cancer therapy
  • endoplasmic reticulum stress
  • oxidative stress
  • cell death
  • dna repair