Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer's disease-related inhibitory circuit dysfunction in adults with Down syndrome.

Olivia BelbinMei-Fang XiaoDesheng XuMaria Carmona-IraguiJordi PeguerolesBessy BenejamLaura VidelaSusana FernándezIsabel BarroetaRaúl Nuñez-LlavesVictor MontalEduard VilaplanaMiren AltunaJordi ClarimónDaniel AlcoleaRafael BlesaAlberto LleóPaul F WorleyJuan Fortea

Published in: Molecular neurodegeneration (2020)

Low levels of CSF NPTX2, a protein implicated in inhibitory circuit function, is common to sporadic and genetic forms of AD. CSF NPTX2 represents a promising CSF surrogate marker of early AD-related changes in adults with DS.

Keyphrases

cerebrospinal fluid
oxidative stress
cognitive decline
late onset
gene expression
dna methylation
copy number
binding protein
amyotrophic lateral sclerosis