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Phenolipids, Amphipilic Phenolic Antioxidants with Modified Properties and Their Spectrum of Applications in Development: A Review.

Silvia Ivonne Arzola-RodríguezLaila Nayzzel Muñoz-CastellanosCesar López-CamarilloErika Salas
Published in: Biomolecules (2022)
Polyphenols, as secondary metabolites from plants, possess a natural antioxidant capacity and biological activities attributed to their chemical and structural characteristics. Due to their mostly polar character, polyphenols present a low solubility in less polar environments or hydrophobic matrices. However, in order to make polyphenols able to incorporate in oils and fats, a transformation strategy is necessary. For the above, the functionalization of polyphenols through chemical or enzymatic lipophilization has allowed the synthesis of phenolipids. These are amphipilic molecules that preserve the natural phenolic core to which an aliphatic motif is attached by esterification or transesterification reactions. The length of the aliphatic chain in phenolipids allows them to interact with different systems (such as emulsions, oily molecules, micelles and cellular membranes), which would favor their use in processed foods, as vehicles for drugs, antimicrobial agents, antioxidants in the cosmetic industry and even in the treatment of degenerative diseases related to oxidative stress.
Keyphrases
  • oxidative stress
  • ionic liquid
  • drug delivery
  • ms ms
  • hydrogen peroxide
  • nitric oxide
  • drug release
  • cancer therapy
  • hyaluronic acid
  • heat stress
  • replacement therapy
  • endoplasmic reticulum stress
  • smoking cessation