The relationship between plasma clozapine concentration and clinical outcome: a cross-sectional study.

Yuji YadaKohei KitagawaShinji SakamotoAtsushi OzawaAkihiro NakadaHiroko KashiwagiYuko OkahisaSoshi TakaoManabu TakakiYoshiki KishiNorihito Yamada

Published in: Acta psychiatrica Scandinavica (2020)

The AGNP therapeutic reference range (350-600 ng/ml) is useful, and a dose above 1000 ng/ml is potentially more effective but carries the risk of severe ADRs in the central nervous system.

Keyphrases

physical activity
early onset
cerebrospinal fluid
risk factors
drug induced