GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.

Nikhil R Gandasi Rui Gao Lakshmi Kothegala Abigail Pearce Cristiano Santos Samuel Acreman Davide Basco Anna Benrick Margarita V Chibalina Anne Clark Claudia Guida Matthew Harris Paul R V Johnson Jakob G Knudsen Jinfang Ma Caroline Miranda Makoto Shigeto Andrei I Tarasov Ho Yan Yeung Bernard Thorens Ingrid Wernstedt Asterholm Quan Zhang Reshma D Ramracheya Graham Ladds Patrik Rorsman

Published in: Diabetologia (2023)

We conclude that the GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of glucagon secretion. We propose that the increase in circulating glucagon observed following genetic/pharmacological inactivation of glucagon signalling in mice and in people with type 2 diabetes reflects the removal of GLP-1(9-36)'s glucagonostatic action.

Keyphrases

endothelial cells
metabolic syndrome
genome wide
copy number
drug induced