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RNA Modification in Inflammatory Bowel Diseases.

Mika NakayamaYuki OzatoYoshiko TsujiYasuko AraoChihiro OtsukaYumiko HamanoGenzo SumiKen OfusaShziuka UchidaAndrea VecchioneHideshi Ishii
Published in: Biomedicines (2022)
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa, which is caused by a combination of factors. These include genetic and epigenetic alterations, environmental influence, microorganism interactions, and immune conditions. Some populations with IBD show a cancer-prone phenotype. Recent studies have provided insight into the involvement of RNA modifications in the specific pathogenesis of IBD through regulation of RNA biology in epithelial and immune cells. Studies of several RNA modification-targeting reagents have shown preferable outcomes in patients with colitis. Here, we note a new awareness of RNA modification in the targeting of IBD and related diseases, which will contribute to early diagnosis, disease monitoring, and possible control by innovative therapeutic approaches.
Keyphrases
  • ulcerative colitis
  • nucleic acid
  • oxidative stress
  • gene expression
  • dna methylation
  • cancer therapy
  • drug delivery
  • young adults
  • adipose tissue
  • copy number
  • insulin resistance
  • human health