Amyloid precursor protein 𝛽CTF accumulates in synapses in sporadic and genetic forms of Alzheimer's disease.

Paula Ferrer-RaventósDavid Puertollano-MartínMarta Querol-VilasecaÉrika Sánchez-AcedNatalia Valle-TamayoAlba Cervantes-GonzalezRaúl Nuñez-LlavesJordi PeguerolesOriol Dols-IcardoMaria Florencia IulitaIban AldecoaLaura Molina-PorcelRaquel Sánchez-ValleJuan ForteaOlivia BelbinSònia SirisiAlberto Lleó

Published in: Neuropathology and applied neurobiology (2023)

We demonstrate that 𝛽CTF accumulates in synapses in SAD, ADAD and DS. This finding might suggest a role for 𝛽CTF in synapse degeneration. Therapies aimed at mitigating 𝛽CTF accumulation could be potentially beneficial in AD.

Keyphrases

cognitive decline
gene expression
dna methylation
amyotrophic lateral sclerosis
small molecule