The Zinc Transporter Zip7 Is Downregulated in Skeletal Muscle of Insulin-Resistant Cells and in Mice Fed a High-Fat Diet.
Shaghayegh NorouziJohn AdulcikasDarren C HenstridgeSabrina SondaSukhwinder Singh SohalStephen MyersPublished in: Cells (2019)
These data suggest that Zip7 plays a role in skeletal muscle insulin signaling and is downregulated in an insulin-resistant, and HFD state. Understanding the molecular mechanisms of Zip7 action will provide novel opportunities to target this transporter therapeutically for the treatment of insulin resistance and type 2 diabetes.
Keyphrases
- insulin resistance
- high fat diet
- type diabetes
- skeletal muscle
- glycemic control
- high fat diet induced
- adipose tissue
- polycystic ovary syndrome
- induced apoptosis
- metabolic syndrome
- cardiovascular disease
- oxidative stress
- cell proliferation
- endoplasmic reticulum stress
- combination therapy
- deep learning
- big data
- replacement therapy
- weight loss
- data analysis
- smoking cessation
- signaling pathway