A covalent organic framework with a self-contained light source for photodynamic therapy.

Wen-Xiu RenFei KongYu-Qing ShaoQing-Yun HuangLong-Fei SunJie Feng Yu-Bin Dong

Published in: Chemical communications (Cambridge, England) (2022)

External light-independent antitumor PDT is successfully realized with a covalent organic framework (COF)-based host-guest nanosystem. Its highly effective antitumor behavior is fully demonstrated by both H 2 O 2 -overexpressed 4T1 and H 2 O 2 -less expressed HCT116 and MCF-7 xenograft models.

Keyphrases

photodynamic therapy
water soluble
fluorescence imaging
breast cancer cells
cell proliferation
cell death