HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma.

Tao ChenYun-Na TaoYan WuXu RenYun-Fei LiYu-Hai Wang

Published in: Molecular biology reports (2023)

Taken together, HSP70 activation exerted protective effects against neuronal trauma via inhibition of necroptosis. Mechanistically, the HSP90α-mediated activation of RIPK3 and MLKL is involved in these effects.

Keyphrases

heat shock protein
heat shock
heat stress
cerebral ischemia
subarachnoid hemorrhage
oxidative stress
brain injury