Genetic loci for resistance to podocyte injury caused by the tensin2 gene deficiency in mice.
Yuki TakahashiHayato SasakiShiori OkawaraNobuya SasakiPublished in: BMC genetics (2018)
These data indicate that the resistance to podocyte injury caused by tensin2 dysfunction is mainly produced by the effects of the modifier genes on the two loci. The identification of these modifier genes is expected to help elucidate the mechanism underlying podocyte injury.
Keyphrases
- genome wide
- dna methylation
- diabetic nephropathy
- copy number
- bioinformatics analysis
- high glucose
- genome wide identification
- genome wide association study
- oxidative stress
- endothelial cells
- big data
- type diabetes
- high fat diet induced
- genome wide analysis
- artificial intelligence
- replacement therapy
- machine learning