JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in the evaluation of virus neutralization.

Laura Collignon Kenn HolmbeckAshley JustLieven VerhoyeRodrigo Velázquez-MoctezumaUlrik FahnøeThomas H R CarlsenMansun LawJannick Prentoe Troels Kasper Høyer Scheel Judith Margarete GottweinPhilip MeulemanJens Bukh

Published in: Hepatology (Baltimore, Md.) (2024)

These mouse-selected HCV recombinants enable the triage of new vaccine-relevant antibodies in vitro and further allow characterization of protection from infection in vivo using identical viruses in human liver chimeric mice. As such, these viruses will serve as important resources in testing novel antibodies and can thus guide strategies to develop an efficient protective vaccine against HCV infection.

Keyphrases

hepatitis c virus
human immunodeficiency virus
copy number
emergency department
cell therapy
genome wide
stem cells
dengue virus
adipose tissue
gene expression
hiv infected