Heterogeneity, inherent and acquired drug resistance in patient-derived organoid models of primary liver cancer.

Linfeng XianPei ZhaoXi ChenZhimin WeiHongxiang JiJun ZhaoWenbin LiuZishuai LiDonghong LiuXue HanYouwen QianHui DongXiong ZhouJunyan FanXiaoqiong ZhuJianhua YinXiaojie TanDongming JiangHongping YuGuang-Wen Cao

Published in: Cellular oncology (Dordrecht) (2022)

HCC organoids perform better than PDX for drug screening. Acquired sorafenib resistance in organoids promotes HCC aggressiveness via facilitating stemness, retro-differentiation and EMT. Phosphorylated S6 kinase may be predictive for drug resistance in HCC.

Keyphrases

epithelial mesenchymal transition
single cell
emergency department
protein kinase
adverse drug