Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling.

Zhi-Lei Chen Xiang-Nan Li Chun-Xiang Ye Hong-Yu Chen Zhen-Jun Wang

Published in: OncoTargets and therapy (2020)

Our studies verified that circRUNX1 functions as a tumor promotor in CRC cells by targeting the miR-145-5p/IGF1 signaling pathway and may have potential use as a prognostic indicator and therapeutic target in CRC patients.

Keyphrases

pi k akt
signaling pathway
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
binding protein
single cell
prognostic factors
epithelial mesenchymal transition
oxidative stress
growth hormone
case control