LK-DFBA: a linear programming-based modeling strategy for capturing dynamics and metabolite-dependent regulation in metabolism.

LK-DFBA allows for calculation of metabolite concentrations and considers metabolite-dependent regulation while still retaining many computational advantages of FBA. This provides the proof-of-principle for a new metabolic modeling framework with the potential to create genome-scale dynamic models and the potential to be applied in strain engineering tools that currently use FBA.