The prognostic significance of immune microenvironment in breast ductal carcinoma in situ.

Michael S TossAsima AbidiDorothea LescheChitra JosephSakshi MahaleHugo SaundersTanjina KaderIslam M MiligyAndrew R GreenKylie L GorringeEmad A Rakha

Published in: British journal of cancer (2020)

Immunosuppressive proteins are potential markers for high risk DCIS and disease progression. Different stromal and intratumoural lymphocyte composition between pure DCIS, DCIS associated with IBC and invasive carcinoma play a potential role in their prognostic significance and related to the underlying genomic instability. Assessment of overall TILs provides a promising tool for evaluation of the DCIS immune microenvironment.

Keyphrases

stem cells
bone marrow
copy number
gene expression
human health
genome wide