Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry.
Chang XuDanli PengJialu LiMeihua ChenYujie HuMingliang HouQingjuan ShangQi LiangJie LiWenfeng LiXiaoli WuChangbao LiuWanle HuMao CaiHuxiang ZhangGuorong ChenLingling YuXiaoqun ZhengFeizhao JiangJu LuanShengnan JinChunming DingPublished in: BMC medical genomics (2020)
Automated MALDI-TOF MS offers an efficient and cost-effective platform for highly multiplexed quantitation of 299 somatic mutations, which may be useful in studying the biological and clinical significance of somatic mutations with large numbers of cancer tissues.
Keyphrases
- mass spectrometry
- liquid chromatography
- high throughput
- high performance liquid chromatography
- copy number
- gas chromatography
- capillary electrophoresis
- machine learning
- deep learning
- high resolution
- single cell
- ms ms
- papillary thyroid
- tandem mass spectrometry
- squamous cell carcinoma
- young adults
- liquid chromatography tandem mass spectrometry
- solid phase extraction