Aqueous Ring-Opening Polymerization-Induced Self-Assembly (ROPISA) of N-Carboxyanhydrides.
Chloé GrazonPedro Salas-AmbrosioEmmanuel IbarboureAlix BuolElisabeth GarangerMark W GrinstaffSe Bastien LecommandouxColin BonduellePublished in: Angewandte Chemie (International ed. in English) (2019)
Reported here is the first aqueous ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs) using α-amino-poly(ethylene oxide) as a macroinitiator to protect the NCA monomers from hydrolysis through spontaneous in situ self-assembly (ISA). This ROPISA process affords well-defined amphiphilic diblock copolymers that simultaneously form original needle-like nanoparticles.