Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis.

Chih-Huang LiXiaolei TangSamiksha WasnikXiaohua WangJintao ZhangYi XuKin-Hing William LauH Bryant NguyenDavid J Baylink

Published in: BMC infectious diseases (2019)

Because FGF-23 and IGF-1 have multiple biological functions besides their role in regulating kidney 1α-hydroxylase, our data suggest that FGF-23 and IGF-1 are warranted for further investigation as potential agents for the correction of 1,25(OH)2D deficiency and for the improvement of survival among sepsis patients.

Keyphrases

human health
intensive care unit
acute kidney injury
end stage renal disease
ejection fraction
newly diagnosed
septic shock
peritoneal dialysis
pi k akt
binding protein
electronic health record
machine learning
patient reported outcomes
free survival
data analysis