A Luminescent Manganese PhotoCORM for CO Delivery to Cellular Targets under the Control of Visible Light.
Jorge JimenezIndranil ChakrabortyAnnmarie DominguezJorge Martinez-GonzalezW M Chamil SameeraPradip K MascharakPublished in: Inorganic chemistry (2018)
A photoactive manganese carbonyl complex derived from dansylimidazole (Imdansyl), namely, [Mn(Imdansyl)(CO)3(phen)](CF3SO3) (1), has been synthesized and structurally characterized. This is the first luminescent manganese carbonyl-based photoCORM reported in the literature. This complex exhibits CO release under the exclusive control of low-power broadband visible light. The corresponding rhenium carbonyl complex, namely, [Re(Imdansyl)(CO)3(phen)](CF3SO3) (2), has also been reported, which is luminescent but sensitive only to UV-B (λ<315 nm) light. The entry of the manganese photoCORM into the human colorectal adenocarcinoma cells (HT-29) has been demonstrated with the aid of fluorescence microscopy. Irradiation of the photoCORM-loaded cancer cells to visible light leads to a dose-dependent apoptotic cell death.
Keyphrases
- visible light
- cell death
- quantum dots
- cell cycle arrest
- metal organic framework
- oxide nanoparticles
- energy transfer
- cystic fibrosis
- sensitive detection
- single molecule
- induced apoptosis
- endothelial cells
- systematic review
- squamous cell carcinoma
- drug delivery
- high speed
- photodynamic therapy
- high resolution
- cancer therapy
- endoplasmic reticulum stress
- anti inflammatory
- signaling pathway
- cell proliferation
- wound healing
- pi k akt
- aqueous solution