Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP-Activated Protein Kinase Signaling Pathway.
Tian LanYang YuJing ZhangHaonan LiQiqing WengShuo JiangSong TianTonghao XuSha HuGuizhi YangYan ZhangWeixuan WangLexun WangQing ZhuXianglu RongJiao GuoPublished in: Hepatology (Baltimore, Md.) (2022)
Cordycepin exerts significant protective effects against hepatic steatosis, inflammation, liver injury, and fibrosis in mice under metabolic stress through activation of the AMPK signaling pathway. Cordycepin might be an AMPK activator that can be used for the treatment of NASH.
Keyphrases
- protein kinase
- liver injury
- signaling pathway
- drug induced
- pi k akt
- epithelial mesenchymal transition
- oxidative stress
- induced apoptosis
- skeletal muscle
- mouse model
- nuclear factor
- high fat diet induced
- immune response
- combination therapy
- endoplasmic reticulum stress
- replacement therapy
- inflammatory response
- smoking cessation