Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.

Chunqing Guo Wenjie Liu Zheng Liu Jinyang Cai Xiaofei Yu Hongxia Wang Xia Li Daming Zuo Xixian Jiang Bei Zhang Jinze Liu Arun J Sanyal Puneet Puri Huiping Zhou Xiang-Yang Wang

Published in: Hepatology (Baltimore, Md.) (2023)

We identify a novel hepatocyte-extrinsic pathway governed by the immune receptor SRA that maintains liver homeostasis upon drug insult. Giving that drug (ie, APAP) overdose is the leading cause of acute liver failure, targeting this hepatoprotective SRA-IL-10 axis may provide new opportunities to optimize the current management of drug-induced liver injury.

Keyphrases

liver failure
drug induced
hepatitis b virus
liver injury
emergency department
intensive care unit
transcription factor
binding protein
cancer therapy
mechanical ventilation