Why we should sample sparsely and aim for a higher target: Lessons from model-based therapeutic drug monitoring of vancomycin in intensive care patients.
Tingjie GuoReinier M van HestLucas M FleurenLuca F RoggeveenRob J BosmanPeter H J van der VoortArmand R J GirbesRon A A MathotJohan G C van HasseltPaul W G ElbersPublished in: British journal of clinical pharmacology (2020)
For model-based TDM of vancomycin in ICU patients, sampling more frequently than taking only trough samples adds no value and dosing based on AUC24 = 500 mg·h/L lead to the best POT.