Proteomic assay for rapid characterisation of Staphylococcus aureus antimicrobial resistance mechanisms directly from blood cultures.

Francis DeforetRomain CarrièrePierre L 'Aour DufourRoxane PratChloé DesbiollesNoémie CottinAlicia ReuzeauOlivier Dauwalder Céline Dupieux Anne TristanTiphaine CecchiniJérôme Lemoine François Vandenesch

Published in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2024)

The LC-MS/MS method presented herein demonstrates its ability to provide a reliable determination of S. aureus resistance mechanisms, directly from positive blood cultures and in a short turnaround time, as required in clinical laboratories.

Keyphrases

antimicrobial resistance
staphylococcus aureus
high throughput
solid phase extraction
escherichia coli
molecularly imprinted
mass spectrometry
candida albicans
sensitive detection