An allosteric inhibitor of the PhoQ histidine kinase with therapeutic potential against Salmonella infection.

Carlos A LoberttiIgnacio CabezudoFernán O GizziVíctor BlancatoChristian MagniRicardo L E FurlánEleonora García Véscovi

Published in: The Journal of antimicrobial chemotherapy (2024)

A16B1 selectively inhibits the activity of the Salmonella PhoP/PhoQ system through a novel inhibitory mechanism, representing a promising synthetic hydrazone compound with the potential to function as a Salmonella pathoblocker. This offers innovative prospects for combating Salmonella infections while mitigating the risk of antimicrobial resistance emergence.

Keyphrases

escherichia coli
listeria monocytogenes
antimicrobial resistance
small molecule
risk assessment
climate change
human health
protein kinase