Anti-tumorigenic effects of naive and TLR4-primed adipose-derived mesenchymal stem cells on pancreatic ductal adenocarcinoma cells.
Demet KaçaroğluSeher YaylaciNilgün GürbüzPublished in: Cancer medicine (2024)
These findings underscore the significance of both the naive state and different inflammatory phenotypes of MSCs in the microenvironment and represent a pivotal step toward the development of novel therapeutic approaches for pancreatic cancer. Understanding the intricate interactions between MSCs and cancer cells may open new avenues for targeted interventions in cancer therapy.
Keyphrases
- cancer therapy
- mesenchymal stem cells
- induced apoptosis
- drug delivery
- hiv infected
- umbilical cord
- cell cycle arrest
- toll like receptor
- oxidative stress
- minimally invasive
- stem cells
- inflammatory response
- immune response
- physical activity
- endoplasmic reticulum stress
- cell death
- nuclear factor
- cell proliferation
- skeletal muscle