A longitudinal population-based study identifies THBS2 as a susceptibility gene for intervertebral disc degeneration.

Tsuyoshi DeguchiHiroshi HashizumeChikashi TeraoMasahiro NakajimaMasatoshi TeraguchiHiroshi YamadaSakae TanakaNoriko YoshimuraMunehito YoshidaShiro Ikegawa

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2024)

Our longitudinal study found the genes associated with IDD progression and that genetic factors' impact on IDD differs depending on disc level and age.

Keyphrases

genome wide
copy number
dna methylation
gene expression
genome wide identification