Proton pump inhibitors and dementia: A nationwide population-based study.
Nelsan PourhadiJanet JanbekChristina Jensen-DahmChristiane GasseThomas Munk LaursenGunhild WaldemarPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
After following 1,983,785 individuals for a median of 10 years, 99,384 developed dementia PPIs were used by 21.2% of cases and 18.9% of controls PPI use was associated with increased dementia rate regardless of time of treatment onset Magnitude of associations increased with younger age at diagnosis PPI use was not associated with dementia occurring after age 90 years.