Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion.
Allana Brunna Sucupira DuarteYunierkis Perez-CastilloDanielle da Nóbrega AlvesRicardo Dias de CastroRafael Limongi de SouzaDamião Pergentino de SousaElquio Eleamen OliveiraPublished in: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] (2023)
The objective of this study was to evaluate the antifungal activity of free methyl 3,5 dinitrobenzoate (MDNB) and its nanoemulsion (MDNB-NE) against strains of Candida albicans. Additionally, a molecular modeling study was also carried out to propose the mechanism of action and toxicity of MDNB. These results demonstrated the MDNB-NE presented a droplet size of 181.16 ± 3.20 nm and polydispersity index of 0.30 ± 0.03. MDNB and MDNB-NE inhibited the growth of all strains with minimum inhibitory concentrations of 0.27-1.10 mM. The biological results corroborated the molecular model, which pointed to a multi-target antifungal mechanism of action for MDNB in C. albicans. The study could serve as a basis for further research involving compounds with nitro groups with antifungal.