Association of genetic and sulcal traits with executive function in congenital heart disease.

Lara MaleyeffJane W NewburgerDavid WypijNina H ThomasEvdokia AnagnoustouMartina BruecknerWendy K ChungJohn ClevelandSean CunninghamBruce D GelbElizabeth GoldmuntzDonald J HaglerHao HuangEileen KingPatrick McQuillenThomas A MillerAmi Norris-BrilliantGeorge A PorterAmy E RobertsPatricia Ellen GrantKiho ImSarah U Morton

Published in: Annals of clinical and translational neurology (2023)

We conclude that sulcal measures remain important predictors of cognitive flexibility, and the model predicting executive outcomes is improved by inclusion of potential genetic sources of neurodevelopmental risk. If confirmed, measures of sulcal patterning may serve as early imaging biomarkers to identify those at heightened risk for future neurodevelopmental disabilities.

Keyphrases

congenital heart disease
genome wide
high resolution
copy number
gene expression
metabolic syndrome
risk assessment
adipose tissue
skeletal muscle
fluorescence imaging
photodynamic therapy