Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

Jonathan M Loree Yucai WangMuddassir A SyedAlexey V SorokinOluwadara CokerJoanne XiuBenjamin A Weinberg Ari M VanderWalde Anteneh A Tesfaye Victoria M Raymond Benjamin Miron Gabi TarcicOri ZelichovRussell R BroaddusPatrick Kwok Shing NgKang Jin JeongYiu Huen TsangGordon B Mills Michael James OvermanAxel GrotheyJohn L MarshallScott Kopetz

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

We provide best available evidence to guide treatment when atypical RAS variants are identified. KRAS L19F, Q22K, D33E, and T50I are more prevalent than many guideline-included RAS variants and functionally relevant.

Keyphrases

wild type
metastatic colorectal cancer
copy number
gene expression
dna methylation