Activation of overexpressed glucagon-like peptide-1 receptor attenuates prostate cancer growth by inhibiting cell cycle progression.

Toru ShigeokaTakashi NomiyamaTakako KawanamiYuriko HamaguchiTsuyoshi HorikawaTomoko TanakaShinichiro IrieRyoko MotonagaNobuya HamanoueMakito TanabeKazuki NabeshimaMasatoshi TanakaTashihiko Yanase Daiji Kawanami

Published in: Journal of diabetes investigation (2020)

Forced expression of GLP-1R attenuates prostate cancer cell proliferation by inhibiting cell cycle progression in vitro and in vivo. Therefore, GLP-1R activation might be a potential therapy for prostate cancer.

Keyphrases

cell cycle
prostate cancer
cell proliferation
radical prostatectomy
signaling pathway
pi k akt
binding protein
risk assessment