Possible prognostic impact of PKCι genetic variants in prostate cancer.

Amna HafeezMaria ShabbirKhushbukhat KhanJaneen H TrembleyYasmin BadshahSameen ZafarKanza ShahidHania ShahNaeem Mahmood AshrafArslan HamidTayyaba AfsarAli AlmajwalAfifa MariumSuhail Razak

Published in: Cancer cell international (2024)

Genotypic analysis of two non-synonymous PKCι variants in association with PCa prognosis was performed. Both variants in the PB1 domain showed potential as a prognostic marker for PCa. In silico analysis of the effect of the variants on PKCι protein interactions indicated they may be involved in PCa progression through aberration of epithelial cell polarity pathways.

Keyphrases

prostate cancer
copy number
radical prostatectomy
protein kinase
heavy metals
gene expression
genome wide
small molecule
dna methylation
climate change