Chronic heart failure induces early defenestration of liver sinusoidal endothelial cells (LSECs) in mice.

Kamila Wojnar-Lason Urszula Tyrankiewicz Agnieszka Kij Anna Kurpinska Patrycja Kaczara Grzegorz Kwiatkowski Natalia Wilkosz Magdalena Giergiel Marta Stojak Marek Grosicki Tasnim Mohaissen Agnieszka JasztalZuzanna KurylowiczMarek Szymonski Izabela Czyzynska-Cichon Stefan Chlopicki

Published in: Acta physiologica (Oxford, England) (2024)

Tgαq*44 mice displayed right-sided HF and altered hepatic blood flow leading to LSECs dysfunction involving defenestration, shift in eicosanoid profile, and proteomic changes. LSECs dysfunction appears as an early and persistent event in CHF, preceding congestive hepatopathy and contributing to alterations in lipoprotein transport and CHF pathophysiology.

Keyphrases

blood flow
endothelial cells
high fat diet induced
oxidative stress
type diabetes
insulin resistance
heart failure