Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.

Nirupama PutchaGabriel G PaulAntoine AzarRobert A WiseWanda K O'NealMark T DransfieldPrescott G WoodruffJeffrey L CurtisAlejandro P ComellasM Bradley DrummondAllison A LambertLaura M PaulinAshraf FawzyRichard E KannerRobert PaineMeiLan K HanFernando J MartinezRussell P BowlerR Graham BarrNadia N Hanselnull null

Published in: PloS one (2018)

Subnormal serum IgA levels were associated with increased risk for acute exacerbations, supporting mildly impaired IgA levels as a contributing factor in COPD morbidity. Additionally, a dose-response relationship between lower serum IgA and number of exacerbations was found among individuals with serum IgA in the lowest decile, further supporting the link between serum IgA and exacerbation risk. Future COPD studies should more comprehensively characterize immune status to define the clinical relevance of these findings and their potential for therapeutic correction.

Keyphrases

chronic obstructive pulmonary disease
lung function
cystic fibrosis
liver failure
intensive care unit
respiratory failure
risk assessment
human health
aortic dissection