HBV infection increases the risk of macular degeneration: the roles of HBx-mediated sensitization of retinal pigment epithelial cells to UV and blue light irradiation.

Ruey-Hwang ChouChang-Yin LeeLee-Won ChongKuang-Hsi ChangCheng-Li LinKe-Sin YanChingfu TsouYi-Chao Hsu

Published in: Journal of translational medicine (2018)

The HBx protein may sensitize RPE cells to UV and blue light irradiation and increase the risk of HBV-infection-associated MD through down-regulation of multiple DNA repair pathways.

Keyphrases

hepatitis b virus
dna repair
dna damage
induced apoptosis
liver failure
cell cycle arrest
dna damage response
optical coherence tomography
radiation induced
aqueous solution
small molecule
endoplasmic reticulum stress
age related macular degeneration
pi k akt