Comparative evaluation of memory T cells in COVID-19 patients and the predictive role of CD4+CD8+ double positive T lymphocytes as a new marker.

Yasin Kalpakçı Tuba Hacibekiroglu Gulay Trak Cengiz Karacaer Taner Demirci Havva Kocayigit Cenk Sunu Ceyhun Varim Mesude Falay

Published in: Revista da Associacao Medica Brasileira (1992) (2020)

As disease severity increases in COVID-19 infection, the number of T cell subsets decreases significantly. Suppression of differentiation from naive T cells to effector memory T cells is the result of severe impairment in adaptive immune functions. Peripheral CD4+CD8+ double-positive T cells were significantly reduced in severe disease presentations and may be a useful marker to predict disease severity.

Keyphrases

working memory
early onset
sars cov
dendritic cells
drug induced
antiretroviral therapy