Immediate Transfusion in African Children with Uncomplicated Severe Anemia.
Kathryn MaitlandSarah KiguliPeter Olupot-OlupotCharles EngoruMacpherson MallewaPedro Saramago GoncalvesRobert O OpokaAyub MpoyaFlorence AlarokerJulius NteziyaremyeGeorge ChagalukaNeil KennedyEva NabawanukaMargaret NakuyaCate NamayanjaSophie UyogaDorothy Kyeyune ByabazaireBridon M'bayaBenjamin WabwireGary S FrostImelda BatesJennifer A EvansThomas N WilliamsElizabeth C GeorgeDiana M GibbA Sarah Walkernull nullPublished in: The New England journal of medicine (2019)
There was no evidence of differences in clinical outcomes over 6 months between the children who received immediate transfusion and those who did not. The triggered-transfusion strategy in the control group resulted in lower blood use; however, the length of hospital stay was longer, and this strategy required clinical and hemoglobin monitoring. (Funded by the Medical Research Council and Department for International Development; TRACT Current Controlled Trials number, ISRCTN84086586.).