Cerebrospinal fluid hemoglobin levels as markers of blood contamination: relevance for α-synuclein measurement.

Silvia PaciottiErik StoopsCindy FrançoisGiovanni BellomoPaolo EusebiHugo VandersticheleDavide Chiasserini Lucilla Parnetti

Published in: Clinical chemistry and laboratory medicine (2021)

Our data show the high impact of CSF blood contamination on CSF α-syn levels, highlighting the measurement of Hb concentration as mandatory when assessing CSF α-syn. The thresholds we calculated are useful to classify CSF samples for blood contamination, considering as reliable only those showing a Hb concentration <1,569 μg/L.

Keyphrases

cerebrospinal fluid
risk assessment
drinking water
health risk
human health
electronic health record
heavy metals
big data
climate change
deep learning
red blood cell