Antagonism of stem cell factor/c-kit signaling attenuates neonatal chronic hypoxia-induced pulmonary vascular remodeling.

Karen C YoungEneida TorresDorothy HehreShu WuCleide SuguiharaJoshua M Hare

Published in: Pediatric research (2015)

SCF/c-kit signaling may potentiate chronic hypoxia-induced vascular remodeling by modulating ERK activation. Inhibition of c-kit activity may be a potential strategy to alleviate PH.

Keyphrases

stem cells
signaling pathway
pulmonary hypertension
pi k akt
mesenchymal stem cells
climate change
cell therapy