Characterizing dispersion in bovine liver using ARFI-based shear wave rheometry.


Background: Dispersion presents both a challenge and a diagnostic opportunity in shear wave elastography (SWE). Shear Wave Rheometry (SWR) is an inversion technique for processing SWE data acquired using an acoustic radiation force impulse (ARFI) excitation. The main advantage of SWR is that it can characterize the shear properties of homogeneous soft media over a wide frequency range. SWR was used here to measure the shear properties of bovine liver tissue. Assumptions associated with SWR include tissue homogeneity, tissue isotropy, and axisymmetry of the ARFI excitation.
Objective: Evaluate the validity of the SWR assumptions in ex vivo bovine liver.
Approach: SWR was used to measure the shear properties of bovine liver tissue as a function of frequency, over a large frequency range. Assumptions associated with SWR (homogeneity, isotropy and axisymmetry) were evaluated through measurements performed at multiple locations and probe orientations.
Main results: Measurements of shear properties were obtained over the 25-250 Hz range, and showed a 4-fold increase in shear storage modulus (from 1 to 4 kPa) and over a 10-fold increase in the loss modulus (from 0.2 to 3 kPa) over that decade-wide frequency range. Measurements under different conditions were highly repeatable, and model error was low in all cases.
Significance and Conclusion: SWR depends on modeling the ARFI-induced shear wave as a full vector viscoelastic shear wave resulting from an axisymmetric source; it is agnostic to any specific rheological model. Despite this generality, the model makes three main simplifying assumptions. These results show that the modeling assumptions used in SWR are valid in bovine liver, over a wide frequency band.