Retinal imaging biomarkers of Alzheimer's disease: A systematic review and meta-analysis of studies using brain amyloid beta status for case definition.

Gizem AshrafMyra McGuinnessMuhammad Azaan KhanCzarina ObtinallaXavier HadouxPeter van Wijngaarden

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2023)

We performed a systematic review on retinal imaging and Alzheimer's disease (AD).We only included studies in which cases were based on brain amyloid beta status.Several retinal biomarkers were associated with AD but clinical utility is uncertain.Studies should focus on biomarker-defined AD and use standardized imaging methods.

Keyphrases

high resolution
optical coherence tomography
diabetic retinopathy
case control
white matter
resting state
cognitive decline
functional connectivity
optic nerve
multiple sclerosis
mass spectrometry
fluorescence imaging
brain injury
mild cognitive impairment