Neurofilament light chain as a potential biomarker of disease status in Friedreich ataxia.

Alexandra ClayKristin Marie Obrochta MossRussell K SoonChristopher B Russell David R Lynch

Published in: Journal of neurology (2020)

Because NfL is elevated in patients, but decreases with age and disease progression, our results suggest that age is the critical determinant of NfL in FRDA (rather than clinical or genetic severity).

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
early onset
genome wide
gene expression
copy number
patient reported outcomes
dna methylation