Poly(POG)n loaded with recombinant human bone morphogenetic protein-2 accelerates new bone formation in a critical-sized bone defect mouse model.

Ryo TazawaKentaro UchidaHiroaki MineharaTerumasa MatsuuraTadashi KawamuraHiroyuki SekiguchiKyoko MuneshigeSho InoueGen InoueMasashi Takaso

Published in: Journal of orthopaedic surgery and research (2020)

Our findings suggest the potential of BMP-2 with poly(POG)n as a material, free from animal-derived collagen, for the treatment of large bone defects.

Keyphrases

recombinant human
mouse model
bone regeneration
bone mineral density
soft tissue
bone loss
drug delivery
wound healing
mesenchymal stem cells
postmenopausal women
cancer therapy
combination therapy
risk assessment
human health
climate change