Sinonasal squamous cell carcinoma and EGFR mutations: a molecular footprint of a benign lesion.

Taken together with the specific involvement of EGFR mutations in ISP, a molecular benign lesion trail suggests that 26 (33%) of 80 SNSCCs developed in association with an ISP. SNSCCs with EGFR mutations may be biologically distinct among head and neck cancers.