Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation.
Takahiko ToyonagaTaku KobayashiSatoshi KuronumaAito UenoHiroki KiyoharaShinji OkabayashiOsamu TakeuchiChristopher P F RedfernHideki TeraiRyo OzakiShintaro SagamiMasaru NakanoSally A CoulthardYoichi TanakaToshifumi HibiPublished in: Journal of gastroenterology (2021)
Increased DNA-incorporated dTG may be responsible for thiopurine-induced leukocytopenia through cell apoptosis in IBD patients with NUDT15 mutation.