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Loss of p53-DREAM-mediated repression of cell cycle genes as a driver of lymph node metastasis in head and neck cancer.

Kevin BrennanAlmudena Espín-PérezSerena ChangNikita BediSaumyaa SaumyaaJune Ho ShinSylvia K PlevritisOlivier GevaertJohn B SunwooAndrew J Gentles
Published in: Genome medicine (2023)
In HNC, patient survival is affected by multiple biological processes and is strongly influenced by the tumor immune and stromal microenvironments. In contrast, LNM appears to be driven primarily by malignant cell plasticity, characterized by epithelial dedifferentiation coupled with EMT-independent proliferation and stemness. Our findings postulate that LNM is initially caused by loss of p53-DREAM-mediated repression of cell cycle genes during early tumorigenesis.
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